WebMay 7, 2024 · CircRNAs demonstrate diverse expression patterns in various mammalian cells, including brain, heart, lung, neuron, and tumor cell lines, and play an important biological role in the development and progress of diseases such as cancer.43,44 For example, circRNAs can act as miRNA sponges such as CDR1 (cerebral degeneration … WebJun 7, 2024 · Circular RNAs (circRNAs) are novel members of the noncoding RNA family. Their characteristic covalent closed-loop structure endows circRNAs that are much more stable than the corresponding linear transcript. circRNAs are ubiquitous in eukaryotic cells, and their functions are diverse and include adsorbing microRNAs (miRNAs; acting as …
Emerging Epigenetic Regulation of Circular RNAs in Human Cancer
WebNational Center for Biotechnology Information WebBreast cancer is a frequent disease for which the discovery of markers that enable early detection or prognostic assessment remains challenging. Circular RNAs (circRNAs) are single-stranded structures in closed loops that are produced by backsplicing. CircRNA and messenger RNA (mRNA) are generated co-transcriptionally, and backsplicing and linear … legal arithmetic
Circular RNAs in cancer: opportunities and challenges in …
WebSep 15, 2024 · Based on the abnormal expression pattern of CircRNAs in human malignant tumors, CircRNA-encoded proteins can provide new specific targets for tumor diagnosis and treatment. Glioblastoma (GBM) At present, more coded CircRNAs are found in brain gliomas than in other tumors. This may be related to the increased CircRNAs in neuronal tissues … WebcircRNAs-mediated angiogenesis in human cancers. Circular RNAs CircRNAs are a novel and evolutionarily conserved class of ncRNAs generated by an alternative RNA splicing … WebFeb 3, 2024 · Circular RNAs (circRNAs) are single-stranded circularized RNA molecules produced from back-splicing. Accumulating evidence has shown that circRNA dysregulations are involved in a variety of human disorders, including viral infection ( 1 ), cardiac fibrosis ( 2 ), diabetes ( 3 ), and cancer ( 4 ). legal areas of practice