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Cyclic pifithrin-a

WebMar 15, 2005 · All of the new analogues, Pifithrin-like and polycyclic dehydrated derivatives were assessed for their p53 inactivation potency by measuring survival of cortical neurons, whose death was induced by the DNA-damaging agent etoposide. Pifithrin-alpha like 2f as well as the cyclic dehydrated 6b analogue were found to be one log more potent p53 ... WebCyclic Pifithrin-α hydrobromide. Synonym(s): 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide, Cyclic PFT-α hydrobromide, Pifithrin-α, cyclic, QB102. Empirical Formula (Hill Notation): C 16 H 16 N 2 S · HBr. CAS No.: 511296-88-1. Molecular Weight: 349.29. Compare Product No. Description SDS Pricing; P4236:

Pifithrin-α, p-Nitro, Cyclic (PFN-α) p53 Inhibitor MedChemExpress

WebCyclic Pifithrin-α hydrobromide is the hydrobromide salt form of Cyclic Pifithrin-α, which is a transcriptional inhibitor of p53. CAS No. 511296-88-1 Selleck's Cyclic Pifithrin-α … WebCyclic pifithrin-alpha sensitizes wild type p53 tumor cells to antimicrotubule agent-induced apoptosis Authors Valentina Zuco 1 , Franco Zunino Affiliation 1 Department of … hmi manassas https://changesretreat.com

Cyclic Pifithrin-alpha Hydrobromide 98.0+%, TCI …

WebPifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis. 1 Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α. 2 p -nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α. 3 It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed … WebPifithrin-α, p-nitro, cyclic Pifithrin-α, p-nitro, cyclic is A cell-permeable p53 inhibitor that is more potent & has a longer half-life than Pifithrin-α. 60477-38-5 sc-222177 sc-222177A sc-222177B sc-222177C : 5 mg 10 mg 25 mg 50 mg: $164.00 $300.00 $600.00 1 WebPifithrin-α (PFT-α; Item No. 13326) is a reversible inhibitor of p53-dependent transcription and apoptosis. 1 Cyclic PFT-α, also known as PFT-β, is a stable analog of PFT-α, formed by the condensation of pifithrin-α in solution. 2 It inhibits the growth of the cancer cell lines IGROV-1, A2780, and HCT116 (IC 50 = 23, 77, and 103 μM, respectively). 2,3 At doses … hmi masterclass

Pifithrin-α Sigma-Aldrich

Category:Pifithrin-α, p-Nitro, Cyclic (PFN-α) p53 Inhibitor MedChemExpress

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Cyclic pifithrin-a

Cyclic Pifithrin-Alpha Hydrobromide

WebJul 1, 2008 · In this study, we used cyclic pifithrin-α, a transcriptional inhibitor of p53, to further investigate the relevance of p53 function in the response of tumor cells to … WebCyclic Pifithrin-alpha Hydrobromide 98.0 %, TCI America Fisher Scientific Fisher Scientific Fisher Healthcare Fisher Science Education Sign Up for Email Help & Support …

Cyclic pifithrin-a

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WebCyclic Pifithrin-α hydrobromide is a cyclic analog of pifithrin-α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone-induced cell death in murine …

WebKey features and details. Cell-permeable transcriptional p53 inhibitor. CAS Number: 60477-38-5. Purity: > 99%. Soluble in DMSO to 10 mM. Form / State: Solid. WebJan 23, 2024 · Pifithrin-α (PFT-α) is a small molecule which has been widely used as a specific inhibitor of p53 transcription activity. However, its molecular mechanism of action …

WebApr 1, 2005 · Cyclicpifithrin-α, a well-characterized small-molecule inhibitor of p53-dependent transactivation of p53-responsive genes, was used as positive control (33). Together, these results suggest that... WebJan 23, 2024 · Interestingly, pretreatment with a p53 inhibitor (cyclic pifithrin-α) did not prevent RCX-induced apoptosis, indicating the activation of ERK1/2-mediated apoptosis in HepG2 cells by the p53 ...

WebCyclic Pifithrin-α hydrobromide has been used as p53 inhibitor to study its role in cigarette smoke−induced apoptosis of pulmonary endothelial cells. [ 1] Packaging 5, 10 mg in …

WebPifithrin-α, p-Nitro, Cyclic is a cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% … hmi meyrinWebNov 7, 2005 · Cells were incubated with or without 10 μg/ml CCN1 for 6 h and immunostained and scored for activated Bax. (B) Cells were transfected with either the pBabePuro vector or the same vector expressing GSE56, or were pretreated with 200 μM of cyclic pifithrin for 1 h. Cells were incubated with or without 10 μg/ml CCN1 for 24 h and … hmimmsWebCyclic Pifithrin- α hydrobromide is a cyclic analog of pifithrin- α (Cat. No. 1267), a small molecule inhibitor of p53. Prevents dexamethasone -induced cell death in murine … hmimonimaWebCyclic PFT-α was a stable analog of PFT-α. p-nitro-Cyclic PFT-α, a cell-permeable form of cyclic PFT-α, was found to be one order of magnitude more active than PFT-α in protecting cortical neurons exposed to etoposide. p-nitro-Cyclic PFT-α acted in a p53-dependently but did not block phosphorylation of p53 on Ser15 in response to etoposide … hm immatrikulationsamtWebJul 16, 2004 · A, PFTα does not affect transcription at a GR saturating concentration of dexamethasone ( Dex ). Mouse fibroblast cells stably transfected with the MMTV-CAT … hmim assilWeb以下是丝状支原体山羊亚种PCR检测试剂盒说明书的订购信息： 我司提供PCR试剂盒的类别有流感病毒、副流感病毒、呼吸道合胞病毒、冠状病毒、轮状病毒、杆菌、链球菌、热带病毒等等核酸检测试剂盒。 产品名称 丝状支原体山羊亚种PCR检测试剂盒说明书 英文名称 Mycoplasma myco hmi messageWebPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. - Find MSDS or SDS, a COA, data sheets and more information. hmi messen