WebNov 16, 2015 · Growth arrest–specific 6 (GAS6) is upregulated in failing human hearts, pressure overload–induced murine hypertrophic hearts, and angiotensin II–treated hypertrophic cardiomyocytes. For the first time, GAS6 is shown to accelerate the development of pressure overload–induced cardiac hypertrophy, fibrosis, and heart failure. WebPurpose of review: Growth arrest-specific gene 6 (Gas6) belongs to the family of vitamin K-dependent coagulation proteins, but in contrast to its other members, has only a limited role in hemostasis. Instead, Gas6 plays a prominent role in conditions of injury, inflammation and repair. Gas6 amplifies the activation of various cell types including endothelial cells …

Pleiotropic role of growth arrest-specific gene 6 in ... - NARCIS

WebApr 12, 2024 · Growth Arrest-Specific Gene 6 (Gas6) Gas6 is a vitamin K-dependent glycoprotein known to be involved in many homeostatic functions, as well as in regulating inflammatory responses. In physiological conditions, plasma Gas6 levels are usually low, while they increase in the case of inflammation ... WebThe product of growth arrest-specific gene 6 (Gas6) is a unique vitamin K-dependent autocrine growth factor for mesangial cells, and warfarin inhibits mesangial cell proliferation by interfering with the activation process of Gas6. A recent series of studies has revealed the in vivo roles of Gas6 and its receptor Axl in the progression of acute ... real betis u19 vs granada u19

Growth arrest-specific gene 6 expression in human breast cancer

WebDysregulation of circulating Gas6 is associated with renal disease and inversely proportional to renal function. Low albumin and higher IV iron administration were associated with higher Gas6 levels, suggesting a possible connection between inflammation and oxidative stress mediated by iron. ... Growth arrest-specific gene 6 (Gas6) levels are ... WebGrowth arrest-specific gene 6 (Gas6) belongs to the family of vitamin K-dependent coagulation proteins, but in contrast to its other members, has only a limited role in … WebGAS6 (growth arrest-specific 6) belongs structurally to the family of plasma vitamin K-dependent proteins. GAS6 has a high structural homology with the natural anticoagulant … real betis u19 vs granada cf u19