WebMar 21, 2024 · KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include Microcephaly With Or Without Chorioretinopathy, … Web強迫性障害と抗精 神 病薬による欠陥症候群(NIDS)の合併例に抗精 神 病薬中止とSSRIが奏効した一例 [Case of obsessive-compulsive disorder associated with neuroleptics-induced deficit syndrome (NIDS): successfully treated by discontinuation of neuroleptics followed by SSRI.]. 精 神 神 経学雑誌 [Seishin Shinkeigaku Zasshi] (in Japanese). 107 (7): 667–673.
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WebNov 15, 2016 · KLF11 is a Krüppel -like factor (KLF) family member, which plays a central role in cardiac hypertrophy and cerebrovascular protection during ischemic insults. … WebKLF11 is a mesoderm derived, zinc finger transcription factor in the Krüppel-like factor (KLF) family. It binds to SP1- like GC- rich sequences in epsilon and gamma globin gene promoters inhibiting cellular growth and causing apoptosis.
WebJan 27, 2024 · KLF11 recruited SIN3A/HDAC to suppress the transcriptional output of YAP/TEAD, which, in turn, promoted KLF11 transcription, forming a negative feedback loop. However, in CSCs, this negative feedback was lost because of epigenetic silence of KLF11, causing sustained YAP activation. Low KLF11 was associated with poor prognosis and … WebSep 24, 2013 · In KRAS-mutant pancreatic cancer cells, activated ERK phosphorylates KLF11, disrupting KLF11–SIN3A interactions and impairing TGFβ-induced growth inhibition 11,108 . Thus, both KLF10 and KLF11 ...
WebJan 10, 2014 · It is found that KLF11 was increased following H/R and reached the highest level with 24 h hypoxia followed by 12 h reoxygenation, suggesting that KLf11 may be … WebDec 13, 2024 · KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. Taken together, our findings identify a novel anti-hypertrophic and anti-fibrotic role of KLF11, and KLF11 activator may serve as candidate drug for heart failure patients.
WebJan 10, 2014 · However, the role of KLF11 in cardiovascular system is unknown. Here in the present study, we identify KLF11 as a negative transcription factor in the development of …
WebKLF11 (MODY7, TIEG2, Tieg3) protein expression summary. The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. ent stobhill hospitalWebKLF11 is a zinc finger transcription factor member of the Sp1/KLF family of transcription factors that is composed of 17 different proteins ubiquitously expressed in human tissues (Lomberk and Urrutia, 2005). ... Although KLFs have been studied in the heart, immune system, and gut, here we will focus on the role that KLFs play in the ... dr hoke west palm beach flWebFeb 7, 2014 · Neve et al. (2005) sequenced the KLF11 gene in 190 probands of families with early-onset type II diabetes mellitus and identified a SNP (A349S; 603301.0001) in affected members of a 4-generation family and another SNP (T220M; 603301.0002) in affected members of 2 unrelated multigenerational families. Neither SNP was found in 313 … entstehung von new york cityWebJan 1, 2005 · KLF11 is a member of the Sp1/KLF family of transcription factors and is expressed in many tissues [2], [8]. ... Total RNA was isolated from brain, heart, kidney, liver, lung, muscle, spleen, testes, and thymus using TRIZOL reagent (Invitrogen). RT–PCR was carried out using the primers that are specific for KLF11 and KLF13. dr ho knee painWebJan 10, 2014 · KLF11 is expressed ubiquitously and participates in diabetes and regulates hepatic lipid metabolism. However, the role of KLF11 in cardiovascular system is largely … entstehung sydney opera houseWebJan 27, 2024 · As KLF11 affected the chemotherapy tolerance of osteosarcoma cells (figs. S4I and S5, E and F), and the average levels of KLF11 were higher in the good-response group than poor-response patients (fig. S14H), we explored whether KLF11 expression could predict the clinical response to chemotherapy in patients with osteosarcoma. ent st marys isle of wightWebRole of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function Bernadette Nevea, Martin E. Fernandez-Zapicob, Vered Ashkenazi-Katalanc, Christian Dinaa, Yasmin H. Hamidd, Erik Jolye, Emmanuel Vaillanta, Yamina Benmezrouaa, Emmanuelle Duranda, Nicolas Bakahera, Valerie Delannoya, Martine … ent st marys hospital london