Klf5 is required
WebFeb 21, 2024 · Here we report that, in human and mouse prostates, Klf5 is expressed in both basal and luminal cells, with basal cells preferentially expressing acetylated Klf5. Functionally, Klf5 is... WebMar 17, 2024 · These findings indicate that while KLF5 is indispensable for tumor formation, acetylation renders KLF5 less potent in tumor growth but able to maintain a mesenchymal …
Klf5 is required
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WebOct 27, 2024 · The KLF5 protein participated in the core-regulatory circuitry together with co-factors (BRD4, MED1, and RAD21), which constructs the three-dimensional genome … WebDec 1, 2010 · Klf5 is required for normal mouse pre-implantation development. (A) Confocal cross-sections showing DIC images (top) and Klf5 (middle) and Draq5 nuclei (bottom) …
WebMar 30, 2024 · Studies in many cell lines have shown that KLF5 is an important growth promoting and differentiation inhibitory gene (Rane et al., 2024 ). Recently, some researches have reported that KLF5 plays a key role in the regulation of angiogenesis ( Ci et al., 2015 ), but whether it regulates angiogenesis in liver fibrosis has not been explored. WebSep 1, 2008 · KLF5 regulates genes controlling paracrine interactions during lung morphogenesis, as well as those regulating the maturation of the respiratory epithelium that is required for lung function after ...
WebOct 15, 2016 · Klf5 is also required for adipocyte differentiation. In 3T3-L1 preadipocytes, Klf5 is induced at an early stage of differentiation by C/EBPβ and δ, which is followed by expression of PPARγ 2 ( Oishi et al., 2005 ). We previously reported that Klf5 acts as a regulator of lipid metabolism in skeletal muscle ( Oishi et al., 2008 ). WebMar 17, 2024 · Acetylation of KLF5 is required for TGF-β to induce EMT. TGF-β is a master regulator of EMT 45, a process believed to promote tumor metastasis 25. We thus tested whether acetylation of KLF5 is involved in EMT.
WebOct 1, 2011 · In the present study, we demonstrate that KLF5 is required for normal maturation of the murine bladder urothelium and suggest that Grhl3 and Pparγ are candidate transcriptional downstream targets that mediate this process. Deletion of Klf5 from the developing bladder urothelium causes prenatal VUR, hydroureter, and hydronephrosis.
WebKrüpple-like factor 5 (KLF5) is required for the development of the embryo and multiple organs, such as the lung and intestine. KLF5 plays a pro-proliferative and oncogenic role in several carcinomas, including breast cancer. tinari greenhousesWebLiberti et al. show that Klf5 is required to maintain alveolar epithelial type 1 (AT1) versus type 2 (AT2) cell fate during murine lung development. Furthermore, they demonstrate that Klf5 represses adult AT2 cell responsiveness to inflammatory signaling to inhibit proliferation and promote differentiation during lung regeneration after acute injury. tinari law firmWebJun 11, 2024 · We conclude that Klf5 is required for the normal function of the hepatobiliary system and that the K5-Cre; Klf5fl/fl mouse is an excellent model to probe the molecular events interlinking damage and regenerative response in the liver. Introduction tina ries rnfWebOct 27, 2024 · KLF5 has been reported as a lineage-survival oncogene whose expression is upregulated in specific cancer types, such as squamous carcinoma (e.g., head and neck cancer, oesophageal cancer) and... party arty 2023WebJul 29, 2014 · Rapid replacement of Klf5-mutant crypts with wildtype cells and reduction of stem cell markers suggests further that Klf5 is required for self renewal of intestinal stem cells. Discover the world ... tina rings facebookWebHere, we show that the Klf5-deficient embryos fail to implant due to defective trophectoderm development.We also show that Klf5 is required for the derivation of ESCs from ICM cells. Interestingly, Klf5-deficient ESCs can be established by knocking out both Klf5 alleles in mouse ESCs. The Klf5 knockout (KO) ESCs can maintain pluripotency but show increased … party arty nelsonWebHere, we show that Klf5 is required for the formation of the trophectoderm (TE) and the inner cell mass (ICM), and for repressing primitive endoderm (PE) development. Although cell polarity appeared normal, Klf5 mutant embryos arrested at the blastocyst stage and failed to hatch due to defective TE development. party arty rapper