Webthat MafB, a dominant transcriptional regulator of mature microglia, is involved in the pathology of a mouse model of neuropathic pain. PNI caused a rapid and marked increase of MafB expression selectively in spinal microglia but not in neurons. We also found that the microRNA mir-152 in the spinal cord which targets MafB expression WebFeb 8, 2024 · Abstract. Microglia are resident immune cells that play critical roles in maintaining the normal physiology of the central nervous system (CNS). Remarkably, …

National Center for Biotechnology Information

WebJul 17, 2015 · To determine whether MafB expression is regulated by extrinsic cytokines, we examined GFP fluorescence of primary microglia from Mafb GFP/+ mice by flow cytometry. Notably, GM-CSF treatment drastically reduced GFP fluorescence compared to FBS alone and M-CSF treatment (Fig. 2B).Consistent with the data from flow cytometry, the Mafb … WebMicroglia, which are pathological effectors and amplifiers in the central nervous system, undergo various forms of activation. A well-studied microglial-induced pathological … open source smart lock

Transcription factor MafB contributes to the activation of spinal ...

WebMicroglia-specific knockout of MafB led to disruption of homeostasis in adulthood and increased expression of interferon and inflammation pathways. We found that microglia … Web転写因子MafBは神経障害性疼痛の発現に寄与する脊髄ミクログリアの活性化過程を介在する(Transcription factor MafB mediates activation process of spinal microglia that contributes to neuropathic pain development)(英語)(会議録) WebIn the brain, Mafb -mCherry was detectable in microglia, and YFP expression was found in nearly all such cells ( Fig. 2 B and Fig. S1 B). In the blood, Mafb -mCherry expression was detectable only faintly (not depicted); however, YFP expression was observed in ∼10% of Ly-6C hi monocytes and ∼40% of Ly-6C lo monocytes ( Fig. 2 C and Fig. S1 C). open source smart home software