WebDec 14, 2015 · An immortalised embryonic striatal cell model of HD (StHdhQ111) was stimulated with epidermal growth factor in order to determine whether the subcellular localisation of huntingtin is dependent on kinase signalling pathway activation. Aberrant phosphorylation of AKT and MEK signalling pathways was identified in cells carrying … WebSimilarly, StHdh cells exhibited a similar pattern, with a reduction in nuclear detection as measured by the N/P ratio from 15 mins of EGF stimulation when using Ab109115 (p < 0.05) and in both ...
Huntingtin Subcellular Localisation Is Regulated by Kinase ... - PLOS
Webstriatal derived cell line from a knock in transgenic mouse containing homozygous Huntingtin (HTT) loci with a humanized Exon 1 with 111 polyglutamine repeats; **Please … WebOct 1, 2011 · Both assays showed that in STHdh Q111/111 cells apoptotic cell death was higher with prolonged treatment. A previous report described increased cell death from a pharmacologically unrelated ER stressor, thapsigargin, an inhibitor of the ER calcium sarco (endo)plasmic reticulum Ca 2+ -ATPase (SERCA) pump ( Duennwald and Lindquist, 2008 ). pro health medical pittston pa
HD Community Biorepository Cell Line Description …
WebFeb 1, 2024 · SMAD expression in mouse StHdh cell lines and human NPC cells. RQ values for Smad TF expression in A. StHdh Q111 cell lines and B. hiPSC-derived NSCs measured by qRTPCR both prior to, and following 2 h stimulation with 100 ng/ml TGFβ1. * p < 0.05, ** p < 0.01, *** p < 0.001. Asterisks denote a significant difference between cell lines, hashes ... WebCell type=Neuron. Dominant phenotypes produced by the HD mutation in STHdh (Q111) striatal cells. Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered … WebCell Line Name STHdhQ7/Q7 Description Striatal derived cell line from a knock in transgenic mouse containing homozygous Huntingtin (HTT) loci with a humanized Exon 1 … pro health meriden so broad st